Fundamental nonlinear imaging versus harmonic imaging with contrast medium sonovue in the evaluation of the hepatic focal lesions: Preliminary results


Topic:  Contrast Media
Presentation Time: Friday, 2:45 p.m.
V. Migaleddu, A. Manca, D. Turilli, P. Luciano, N. Canu, G. Campisi, G. Virgilio; Sassari/IT
Presentation Number: B-126
Purpose: To compare the results obtained with contrast medium (SonoVue) and ultrasonography using two different low mechanical index softwares (CCI and CPS).
Methods and Materials: Fifty one patients (28 males; mean age 57.2; age range 32-79 years) were included. 78 lesions examined: 33 HCC, 2 FNH, 1 adenoma, 20 haemangioma, 15 metastasis and 7 regenerative nodules. Fundamental nonlinear imaging (CPS) was compared with harmonic imaging (CCI); both softwares used low mechanical index. Exams were performed with Sequoia 512 (Acuson-Siemens) after venous bolus injection of SonoVue (Bracco-I) (2.5ml/8mcl/ml). Penetration, detail and contrast resolution were evaluated independently on stored clips by two blinded observers using Wilcoxon sign sum rank test.
Results: CPS with nonlinear fundamental contrast imaging, in some cases associated with tissue fundamental response, permit to obtain more information than CCI harmonic contrast imaging considering penetration, detail and contrast resolution (P<0.0001 at Wilcoxon sign rank test). In all the cases CPS render intensity response up to 30dB higher than CCI. The differences between the two observers were negligable and non significant from the statistical point of view (P > 0.05.)
Conclusion: Contrast nonlinear fundamental imaging gives us more information than contrast harmonic imaging. Coupled tissue and contrast responses present in this new modality of imaging, allow to obtain a higher diagnostic confidence.