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Scuola di Formazione Specialistica di Eco Color Doppler - SIUMB
Case of the month
Leydig cell tumor US finding in older male

Conclusions

The Leydig cell tumor in young man cannot be rare, while it is very rare in elder men (only 1%).In this age diagnosis is due to the appearance of the gonadal mass, the malignant form prevails. The conventional US pattern is highly sensitive in locating the testicular tumors (approx 100% of cases).

The US finding is usually a hypoechoic homogeneous mono-lateral mass with clear borders [5-11]. Hyperechoic, non homogeneous and bilateral forms can also be found [12-14]. This feature is not pathognomonic and all testicular tumors, particularly impalpable ones, should be considered as seminoma until proven otherwise [15].
In patients older than 70-year-old metastasis and lymphoma are the most frequent neoplasms. Ultrasound appearance is not specific and an effective Ultrasonographic semeiology doesn’t exist. Color-Doppler and power-Doppler Us demonstrate increased vascularity in the majority of malignant tumors [16].
This data is not enough for a diagnosis of malignancy and it may be difficult to demonstrate increased blood flow in small neoplasms; especially if the color-Doppler equipment is not sensitive enough to capture slow flows.

Literature reports that peripheral hyper-vascularity in a hypoechoic testicular tumor with little or no internal color-Doppler flow could suggest a suspicious Leydig cell tumor [18].
In our experience gonadal mass and endocrine associated manifestations were absent; the small hypoechoic solid lesion was discovered incidentally. High sensitive color-Doppler ultrasound examination allows to locate a perilesional and minimal intralesional slow flow in the small size lesion, even if a benign character results from the histological final examination [19]. For these reasons we cannot associate lesion’s malignancy with its vascularity. A hypoechoic solid nodule can require a histological examination and orchifuniculectomy.